Basic Parts
| Part Registry | Part Name | Part Type | Description |
|---|---|---|---|
BBa_2508GVGJ |
ARE — antioxidant responsive element | Regulatory (enhancer) | A short enhancer region in DNA that serves as the binding site for the transcription factor Nrf2, enabling the inducible activation of antioxidant and detoxification genes in response to oxidative or electrophilic stress |
Composite Parts
| Part Registry | Part Name | Part Type | Description |
|---|---|---|---|
BBa_259IR3B9 |
Nrf2-ARE Driven EGFP Reporter Construct for Oxidative Stress Detection | Reporter | The ARE-minCMV-EGFP plasmid contains an antioxidant response element (ARE) enhancer upstream of a CMV promoter to enable redox-sensitive transcriptional activation. When oxidative or electrophilic stress activates the Nrf2 transcription factor, Nrf2 binds to the ARE sequence, initiating EGFP expression, thus functioning as a fluorescent reporter of cellular oxidative stress. |